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Semaglutide itself does not directly damage kidneys, but rapid dehydration, nausea, or vomiting can worsen pre-existing kidney issues

Beyond cholesterol numbers, semaglutide reduces systemic inflammation markers and improves insulin resistance, both of which contribute to atherosclerotic disease

Medications also have expiration dates

Insulin resistance is a key driver of fatty liver disease

On the whole, reasons for semaglutide differences are not fully understood and warrant further research, especially studies of real-world weight loss with semaglutide that include people without type 2 diabetes, like this one

However, for those in Pearland, Texas, seeking Ozempic for weight loss, there is optimism